|
KMID : 0369820090390030173
|
|
Jorunal of Korean Pharmaceutical Sciences
2009 Volume.39 No. 3 p.173 ~ p.176
|
|
|
New Crystal form of Valsartan Dipotassium Salt
|
|
Oh Eui-Chaul
Kim Dae-Duk
Seo Sung-Ki
|
|
|
Abstract
|
|
|
|
A new crystal form of valsartan dipotassium was isolated by recrystallization using the one-pot method. The new crystal form was identified as a monohydrate form (C24H27N5O3K2 ·H2O) and characterized by diffential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and X-ray powder diffractometry (PXRD). The new crystal data demonstrated to be clearly different from those known for the tetrahydrate form (C24H27N5O3K2 ·4H2O). It was observed that the monohydrate of vasartan dipotassium salt was completely dissolved in water within 1 hour and its dissolution rate was much faster than anhydrous free form of valsartan.
|
|
|
KEYWORD
|
|
|
Valsartan, Dipotassium Salt, Crystal Form, Hydrate, DSC, TGA, PXRD
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|